Obustavljanje leka - lečenje treba prekidati postepeno. Apstinencijalni simptomi obustave se mogu javiti i kada se lek Bensedin koristi u uobičajenim dozama i u kratkom vremenskom periodu. Videti odeljak “Ako naglo prestanete da uzimate lek Bensedin''.
Ukoliko ste trudni ili dojite, mislite da ste trudni ili planirate trudnoću, obratite se Vašem lekaru ili farmaceutu za savet pre nego što uzmete ovaj lek.
Ukoliko ste lek Bensedin uzimali redovno tokom trudnoće, kod bebe se mogu razviti simptomi obustave leka.
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Nemojte konzumirati alkohol dok ste na terapiji lekom Bensedin. Alkohol može pojačati sedativno dejstvo leka Bensedin i učiniti da se osećate veoma pospano.
Ukoliko je lek propisan ženi u reproduktivnom periodu, treba je upozoriti da se obrati svom lekaru radi obustave terapije ukoliko planira trudnoću ili sumnja da je već trudna.
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Esomeprazol inhibira CYP2C19 metabolički set diazepama. Istovremena primena esomeprazola produžava poluvreme eliminacije i povećava vrednosti PIK diazepama za približno 80%. Pojačano je dejstvo diazepama. Može biti neophodno smanjenje doze diazepama.
Hence, its use is limited to situations of suffering refractory to other prescription drugs, for example nonopioid ache medication.
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Prilikom primene ovog leka postoji rizik od pojave zavisnosti (potreba za stalnim uzimanjem leka). Ovaj rizik se povećava sa povećanjem doze i dužinom trajanja terapije. Rizik je povećan ukoliko ste ranije imali dilemma zloupotrebe alkohola ili lekova.